In order to code for all the 20 amino acids, the code should be made up of three nucleotides. This statement was suggested by
George Gamow, a physicist, who argued that since there are only 4 bases and if they have to code for 20 amino acids, the code should constitute a combination of bases. He also suggested that in order to code for all the 20 amino acids, the code should be made up of three nucleotides.