First slide

Aerobic Respiration

Question

Oxidative decarboxylation is observed in which step of aerobic respiration?

Easy

A

Conversion of oxaloacetic acid to citric acid
B

Conversion of succinic acid to fumaric acid
C

Conversion of phosphoenolpyruvate to pyruvic acid
D

Conversion of pyruvic acid to acetyl CoA

Solution

Pyruvate, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, after it enters mitochondrial matrix undergoes oxidative decarboxylation by a complex set of reactions catalysed by pyruvic dehydrogenase. The reactions catalysed by pyruvic dehydrogenase require the participation of several coenzymes, including NAD+ and Coenzyme A.
$Pyruvic acid + CoA + {NAD}^{+} \to_{Pyruvate dehydrogenase}^{{Mg}^{2}} Acetyl CoA + {CO}_{2} + NADH + H^{+}$

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