Select the incorrect statement w.r.t fluid mosaic model of plasma membrane:

• A

  Integral proteins are partially or totally buried in the membrane.

• B

  The non-polar tail of unsaturated hydrocarbons is protected from the aqueous environment.

• C

  Removal of transmembrane protein requires crude methods of treatments like detergents.

• D

  The polar heads of the lipid are directed towards the inner part of the membrane.