First slide

Mutation

Question

Sickle cell anaemia is:

Easy

A

Caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin
B

Caused by a change in a single base pair of DNA
C

Characterized by elongated sickle like RBCs with a nucleus
D

An autosomal linked dominant trait

Solution

Sickle cell anaemia is due to sickle shaped RBC forme by transversion gene mutation in the gene for beta chain of haemoglobin. The amino acid glutamic acid is replaced by valine.

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