In 1963, two enzymes responsible for restricting the growth of bacteriophage in E.Coli were isolated. They were ……….. and ……… respectively.

In the year 1963, the two enzymes responsible for restricting the growth of bacteriophage in Escherichia coli were isolated. One of these added methyl groups to DNA, while the other cut DNA. The later was called restriction endonuclease.