First slide
Genetic Code
Question

Under which of the following conditions there will be no change in the reading frame of following mRNA?

5' AACAGCGGUGCUAUU 3'

Difficult
Solution

Genetic code is triplet.If we delete GGU from 7th , 8th and 9th position then the entire codon will be deleted. Hence there will not be any change in the reading frame.

Insertion of a single nucleotide alter the reading frame and will lead to frame shift mutation

Deletion of a single nucleotide alter the reading frame and will lead to frame shift mutation.

Addition of A and G will also alter the reading framing as genetic code is triplet.

 

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