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Q.

Under which of the following conditions there will be no change in the reading frame of following mRNA?5' AACAGCGGUGCUAUU 3'

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a

Deletion of GGU from 7th , 8th and 9th positions

b

Insertion of G at 5th position

c

Deletion of G from 5th position

d

Insertion of A and G at 4th and 5th position respectively

answer is A.

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Detailed Solution

Genetic code is triplet.If we delete GGU from 7th , 8th and 9th position then the entire codon will be deleted. Hence there will not be any change in the reading frame.Insertion of a single nucleotide alter the reading frame and will lead to frame shift mutationDeletion of a single nucleotide alter the reading frame and will lead to frame shift mutation.Addition of A and G will also alter the reading framing as genetic code is triplet.

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Under which of the following conditions there will be no change in the reading frame of following mRNA?5' AACAGCGGUGCUAUU 3'