Which scientists worked to determine the biochemical nature of ‘transforming principle’ of Griffith's experiment?

detailed solution

Correct option is C

Avery, McLeod and MacCarty worked to determine the biochemical nature of ‘transforming principle’ in Griffith's experiment. They discovered that protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation, so the transforming substance was not a protein or RNA. Digestion with DNase did inhibit transformation, suggesting that the DNA caused the transformation. They concluded that DNA is the hereditary material, but not all biologists were convinced.