First slide

The Search for Genetic Material

Question

Which scientists worked to determine the biochemical nature of âtransforming principleâ of Griffith's experiment?

Easy

A

Temin and Baltimore
B

Meselson and Stahl
C

Avery, McLeod and MacCarty
D

Bateson

Solution

Avery, McLeod and MacCarty worked to determine the biochemical nature of âtransforming principleâ in Griffith's experiment. They discovered that protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation, so the transforming substance was not a protein or RNA. Digestion with DNase did inhibit transformation, suggesting that the DNA caused the transformation. They concluded that DNA is the hereditary material, but not all biologists were convinced.

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