First slide

Proteins

Question

The main forces that stabilize the $2^{o}$ and $3^{o}$ structures of a protein are.
(A) Hydrogen bonds                     (B) Bisulphide linkages
(C) Vanderwaals forces                (D) Electrostatic forces

Moderate

A

A, B, C only
B

A, B, D only
C

A, B, C, D
D

A, B, only

Solution

$2^{o}$ structure is mainly stabilized by H–bonding.
Overall folding of $2^{o}$ structure represents $3^{o}$ structure.
Thus   $2^{0} and 3^{0} structures are stabilized by$
1) Bisulphide linkages (S – S)
                2) Vanderwaals forces (between alkyl groups)
                3) Electrostatic forces ( $between - {COO}^{-} and - {NH}_{3}^{+}$ )
                4) H-bonds $(between - CO - and - NH - gps)$

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