The most important contribution to the stability of a protein conformation appears to be the

• A

  entropy increase from the decrease in ordered water molecules forming a solvent shell around it

• B

  maximum entropy increase from ionic interactions between the ionized amino acids in a protein

• C

  sum of free energies of formation of many weak interactions between its polar amino acids and surrounding water molecules

• D

  sum of free energies of formation of many weak interactions among the hundreds of amino acids in a protein