Which of the following statements are correct?

A reaction in which different stereoisomers produce different products or act at different rates is called stereospecific reaction.

A reaction in which a given substrate produces diastereoisomeric products in different amounts and where one diastereomer predominates very much overthe other is called stereoselective reaction.

If the replacement of one group at an achiral centre by a new substifuent generates a chiral centre, the original molecule is said to be enantiotopic.

The E and Z system of naming geometrical isomers is based on the CIP sequence rule.