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In gene therapy, to treat ADA deficiency, the patient requires periodic infusion of genetically engineered lymphocytes. What is the reason behind this process?

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cDNA becomes nonfunctional after some time
Lymphocytes cannot divide rapidly
ADA cDNA may undergo mutation
Lymphocytes are not immortal

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detailed solution

Correct option is D

Lymphocytes are not immortal, so that periodic infusión of lymphocytes is required.

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