In gene therapy, to treat ADA deficiency, the patient requires periodic infusion of genetically engineered lymphocytes. What is the reason behind this process?
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a
cDNA becomes nonfunctional after some time
b
Lymphocytes cannot divide rapidly
c
ADA cDNA may undergo mutation
d
Lymphocytes are not immortal
answer is D.
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Detailed Solution
Lymphocytes are not immortal, so that periodic infusión of lymphocytes is required.