Insufficient quantities of antidiuretic hormone in blood lead to

Insufficient quantities of antidiuretic hormone (ADH) in blood lead to diabetes insipidus.The most common abnormality associated with dysfunction of the posterior pituitary is diabetes insipidus (DI). This disorder is due to defects in antidiuretic hormone (ADH) receptors or an inability to secrete ADH. Neurogenic diabetes insipidus results from hyposecretion of ADH, usually caused by a brain tumor, head trauma, or brain surgery that damages the posterior pituitary or the hypothalamus. In nephrogenic diabetes insipidus, the kidneys do not respond to ADH. The ADH receptors may be nonfunctional, or the kidneys may be damaged. A common symptom of both forms of DI is excretion of large volumes of urine, with resulting dehydration and thirst.