Mark the wrong statement about Sickle cell anaemia.
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a
It is an autosome linked recessive trait.
b
It is controlled by a single pair of alleles, HbA and HbS.
c
It is caused by the substitution of Valine by Glutamic acid.
d
In SCA, shape of the RBC becomes elongated sickle like structure.
answer is C.
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Detailed Solution
SCA is caused by the substitution of by Glutamic acid by Valine at the sixth position of the beta globin chain of the haemoglobin molecule. The substitution of amino acid in the globin protein results due to the single base substitution at the sixth codon of the beta globin gene from GAG to GUG.