Q.

Maturation of proinsulin to insulin involves

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a

formation of peptide bonds

b

formation of disulphide bonds

c

cleavage of peptide bonds

d

cleavage of disulphide bonds

answer is C.

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Detailed Solution

In humans, proinsulin consists of 86 amino acids (21 acids of A chain, 30 amino acids of B chain, the C peptide connecting the two has 35 amino acids). During maturation of proinsulin loses C peptide to form insulin. Hence, the peptide bonds are cleaved.Mature insulin has A chain (21 amino acids) and B chain (30 amino acids) bound by disulphide bonds.
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