Q.
Maturation of proinsulin to insulin involves
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a
formation of peptide bonds
b
formation of disulphide bonds
c
cleavage of peptide bonds
d
cleavage of disulphide bonds
answer is C.
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Detailed Solution
In humans, proinsulin consists of 86 amino acids (21 acids of A chain, 30 amino acids of B chain, the C peptide connecting the two has 35 amino acids). During maturation of proinsulin loses C peptide to form insulin. Hence, the peptide bonds are cleaved.Mature insulin has A chain (21 amino acids) and B chain (30 amino acids) bound by disulphide bonds.
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