Most sophisticated and advanced ART among the following is

Intra cytoplasmic sperm injection (ICSI) is a specialised procedure to form an embryo in the laboratory in which a sperm is directly injected into the ovum. It requires highly level precision and sophistication.IUI (intrauterine insemination) is not as advanced as ICSI. It just involves introducing semen into the uterus.IUD (intrauterine device) and MTP (medical termination of pregnancy) are not ARTs.