First slide

Mechanism of Concentration of the Filtrate

Question

The osmolarity is about 1200 mOsmL^-1 in

Moderate

A

inner medullary interstitium of the kidney
B

outer medullary interstitium of the kidney
C

cortical interstitium of the kidney
D

blood

Solution

There is an increasing osmolarity towards the inner medullary interstitium, i.e., from 300 mOsmolL^–1 in the cortex to about 1200 mOsmolL^–1 in the inner medulla. The proximity between the Henle’s loop and vasa recta, as well as the countercurrent in them help in maintaining this gradient.

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