First slide

Muscle

Question

A skeletal muscle deprived of adequate ATP supplies will

Moderate

A

immediately relax
B

enter a state where actin and myosin are unable to separate
C

fire many more action potentials than usual and enter a state of "rigor"
D

sequester all free calcium ions into the sarcoplasmic reticulum

Solution

After death, cellular membranes become leaky. Calcium ions leak out of the sarcoplasmic reticulum into the sarcoplasm and allow myosin heads to bind to actin. ATP synthesis ceases shortly after breathing stops, however, so the cross-bridges cannot detach from actin. The resulting condition, in which muscles are in a state of rigidity (cannot contract or stretch), is called rigor mortis (rigidity of death).

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