Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.
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a
Both are due to a quantitative defect in globin chain synthesis.
b
Thalassemia is due to less synthesis of globin molecules.
c
Sickle cell anaemia is due to a quantitative problem of globin molecules.
d
Both are due to a qualitative defect in globin chain synthesis.
answer is B.
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Detailed Solution
In α Thalassemia, production of α globin chain is affected while in β Thalassemia, production of β globin chain is affected. Alpha globin chain is controlled by two linked genes present on the chromosome 16, while Beta globin chain is controlled by a single gene present on the chromosome 11.