Which of the following best describes Hamburger’s phenomenon?

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Exchange of chloride and bicarbonate ions between the plasma and the RBCs

Effect of carbon dioxide on the oxygen affinity of haemoglobin

Oxygenation of haemoglobin in the lungs displaces carbon dioxide from the blood

The amount of a gas that will dissolve in a liquid is proportional to the partial pressure of the gas and its solubility

answer is A.

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Detailed Solution

The exchange of Cl- and HCO3- ions between the plasma and the RBC is called the chloride shift or Hamburger’s phenomenon. In systemic capillaries, CO2 enters the RBCs and reacts with H2O, in the presence of carbonic anhydrase, to form H2CO3- which dissociates into H+ and HCO3-. Some HCO3- diffuses out into the blood plasma, down its concentration gradient. The plasma membrane of the RBCs is nearly impermeable to cations. To maintain the electrical balance between blood plasma and RBCs, Cl- move from the blood plasma into the RBC.

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