First slide

Human Endocrine System

Question

Which of the following cause osteoporosis?

Moderate

A

Hypersecretion of TCT and hyposecretion of PTH
B

Hypersecretion of oestrogens and hyposecretion of PTH
C

Hypersecretion of oestrogens and hyposecretion of progestogens
D

Hypersecretion of PTH and hyposecretion of oestrogens

Solution

PTH acts on bones and stimulates the process of bone resorption (dissolution / demineralisation). Hypersecretion of PTH thus causes demineralization of bone leading to osteoporosis. Oestrogens decrease the number and activity of osteoclasts. Oestrogen deficiency increases the number of osteoclasts and decreases the number of osteoblasts resulting in overall bone resorption. Oestrogen deficiency can lead to excessive bone resorption accompanied by inadequate bone formation, as commonly observed in postmenopausal women.

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