Which of the following conditions will stimulate parathyroid gland to release parathyroid hormone?
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a
Fall in active Vitamin D levels
b
Fall in blood Ca2+ levels
c
Fall in bone Ca2+ levels
d
Rise in blood Ca2+ levels
answer is B.
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Detailed Solution
Parathyroid hormone is a hypercalcemic hormone. It increases blood Ca2+ levels by stimulating osteoclasts. These cells cause bone resorption. The secretion of parathyroid hormone is regulated by blood calcium level. A fall in blood Ca2+levels stimulate the release of parathyroid hormone leading to release Ca2+into the blood in order to maintain calcium homeostasis. A rise in Ca2+ in blood stimulates the release of thyrocalcitonin which decreases the number and activity of osteoclasts and thereby reducing the Ca2+ levels in the blood.