Mechanism of Hormone Action
Question
Which of the following hormone requires second messenger?
Moderate
Solution
Hormones which interact with membrane-bound receptors normally do not enter the target cell, but generate second messengers (e.g., cyclic AMP, IP3, Ca++ etc.) which in turn regulate cellular metabolism. Insulin is a peptide hormone that binds to membrane receptor.
Cortisol, androgens and thyroxine bind to intracellular receptors and so, do not require secondary messenger.
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