Is it true that the enzymes of the smooth Endoplasmic Reticulum detoxify the drugs and other poisons in blood cells?

A smooth endoplasmic reticulum is a form of endoplasmic reticulum with a smooth surface because it lacks ribosomes, which are the primary source of a rough surface.

The removal of any harmful elements, such as metabolic wastes or medications, is one of the most critical and primary activities of the Smooth Endoplasmic Reticulum.

These detoxification procedures are carried out by the Smooth endoplasmic reticulum found in the liver (an organ well-known for its detoxification and drug-metabolizing abilities).

It contains enzymes that catalyze various processes, including those that convert lipid-soluble medications and metabolic wastes into water-soluble forms that may be easily removed from the body.