Gene therapy involves
Which of the following statements is correct?
Pro-insulin differs from mature insulin in
During the processing of the prohormone “proinsulin” into mature and functional “insulin”, the
Which technique helps to identify a bacterial or viral pathogen in a human body even when its concentration is very low and clinical symptoms are not yet visible ?
The first clinical gene therapy was given in 1990 to a 4-year old girl with
Choose the reasons why transgenic animals are designed and mark the correct option. a. To understand of how genes contribute to disease. b. To produce useful biological products. c. To test the safety of vaccines. d. To study of how genes are regulated. e. To study how genes affect the normal functions of the body.
The world’s first transgenic cow was
Which of the following techniques is now routinely being used to detect HIV in suspected AIDS patients?
Which of the following statements are correct? 1. PCR is now routinely used to detect HIV in suspected AIDS patients. 2. A single-stranded DNA or RNA tagged with a radioactive molecule (probe) is allowed to hybridize to its complementary DNA in a clone of cells followed by detection using autoradiography. 3. ELISA is based on the principle of antigen-antibody interaction. 4. Today transgenic models exist for many human diseases such as cancer, cystic fibrosis, rheumatoid arthritis, and Alzheimer’s.
Match the following and choose the correct option. Column I Column II (A) ADA deficiency (i) α -1 antitrypsin (B) Emphysema (ii) Bone marrow transplantation (C ) Insulin (iii) Diabetes mellitus (D) Rosie (iv) alpha lactalbumin A B C D 1 ii i iii iv 2 i ii iii iv 3 i iv ii i 4 iv iii ii i
Which of the following is present in proinsulin but absent in insulin?
Which of the following disease is characterized by damage to alveolar sac and is treated by the protein a -1 antitrypsin?
Which one of the following vectors is used to replace the defective gene in gene therapy?
The first human hormone produced by recombinant DNA technology is
The two polypeptides of human insulin are linked together by
Which kind of therapy was given in 1990 to a four-year-old girl with adenosine deaminase (ADA) deficiency?
Which of the following statements is not correct ?
Adenosine deaminase is very crucial for the functioning of the
ELISA is based on the principle of
Very low concentration of a bacterium or virus, at a time when the symptoms of the disease are not yet visible, can be detected by
In gene therapy to treat adenosine deaminase deficiency disorder, which of the patients blood cells are used ?
GMO used for the commercial production of humulin is
Select the correct statement w.r.t human insulin production by rDNA techniques.
The permanent cure for Severe Combined Immunodeficiency is
One of the most commonly used for the diagnostic tests for COVID-19 is
Select the correct statement w.r.t insulin molecule.
The first recombinant therapeutic developed by Eli Lilly company is
SCID patients require a periodic infusion of genetically modified lymphocytes even in case of gene therapy because
ELISA is based on the principle
Urine test is generally used to diagnose all of the following, except
In 1990, for the first time, Blease and Andresco attempted gene therapy on a four-year-old girl with the deficiency of the enzyme
Match the following and choose the correct option. Column I Column II (a) Cuscuta (i) Parasitic plant (b) Opuntia (ii) Desert plant (c) Ophrys (iii) Orchid plant (d) Rauwolfia (iv) Medicinal plant
Most of the transgenic animals are
The insulin is first synthesised in the human body as
Rosie, the first transgenic cow, has a transgene for the protein
Mark the correct statement about human insulin developed by Eli Lilly company.
Match the following and choose the correct option. Column I Column II (a) Golden rice (i) Vitamin A enriched rice (b) Gene therapy (ii) Chemical safety testing (c) Transgenic animals (iii) ADA deficiency treatment (d) Rosie (iv) Lactalbumin (a) (b) (c) (d) 1 i iii ii iv 2 iii i ii iv 3 i iii iv ii 4 i ii iii iv
Which of the following statements regarding the structure of proinsulin and mature insulin are not correct? (i) Proinsulin is made up of three polypeptide chains– A, B and C. (ii) C – polypeptide chain with 33 amino acids is removed prior to insulin formation. (iii) Mature insulin is made up of 51 amino acids arranged in two polypeptide chains– A and B. (iv) Polypeptide chain A has 30 amino acids and polypeptide chain B has 21 amino acids. (v) Polypeptide chains A and B are interconnected by only one S – S linkage.
Periodic infusion of genetically engineered lymphocytes is required for the patients suffering from
The ADA gene is crucial for
Which of the following protein is produced by genetic engineering as a cure for diseases like emphysema?
The first clinical gene therapy was given for treating
The transgenic animals are those which have
The two polypeptides of human insulin are linked together by
Majority of transgenic animals are
The site for the production of an enzyme, the deficiency of which causes SCID, in the body is
The first human hormone produced by recombinant DNA technology is
Eli, Lilly, an American company, is famous for
Select the incorrect statement
Which of the following is not the application of transgenic animals?
Nucleic acid segment tagged with a radioactive molecule is called
Match the following and choose the correct option. Column I Column II (a) Addison’s disease (i) Phenylalanine hydroxylase (b) Graves’ disease (ii) Adenosine deaminase (c) PKU (iii) Thyroxine (d) SCID (iv) Cortisol a b c d 1. iii iv i ii 2. iv iii ii i 3. iv iii i ii 4. iii i iv ii
Maturation of proinsulin to insulin involves
